Name |
Icon |
Description |
120 Volt | | Whenever an enemy is shot, it will zap other enemies near them, dealing damage. |
20/20 | File:20 20 Icon.png | Grants double shot. |
3 Dollar Bill | File:3 Dollar Bill Icon.png | Gives Isaac a random tear effect every room. The effect given changes upon entering a room.
File:DLC Indicator.png The effect changes every 3 seconds. |
???'s Only Friend | | Summons a big attack fly that can be controlled with the shooting direction-keys. |
A Quarter | File:A Quarter Icon.png | Adds 25 to Isaac's coin count, capping at 99. |
Abel | | A familiar that mirrors the player's movements and shoots in the opposite direction. |
Akeldama | | While in an uncleared room, Isaac forms trails of bloody tears that drag behind him, bursting and dealing damage upon contact with enemies. |
Almond Milk | | Upgrades fire rate immensely but significantly decreases damage, and tears are given random worm effects. |
Anemic | | +5 Range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room. |
Ankh | | Upon death, the player will respawn as Blue Baby with 3 Soul Hearts. |
Anti-Gravity | | Tears up. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in. |
Aquarius | | A trail of blue creep is left behind Isaac, which damages enemies. |
Aries | | +0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage. |
BBF | | Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds. |
Ball Of Tar | File:Ball Of Tar Icon.png | Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed. |
Best Bud | | When hit, summons a white attack fly similar to Distant Admiration for the current room. |
Big Fan | | Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies. |
Bird Cage | | The first time Isaac takes damage in a room, the familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Dead Bird. |
Bird's Eye | | Adds a chance to shoot a fire instead of a tear, which pierces and can block enemy shots, diminishing in size as it does. |
The Black Bean | | When taking damage, Isaac farts, causing poison damage to all enemies in range. |
Blood Bombs | | Grants 1 heart container. Bombs create puddles of damaging red creep upon exploding. If Isaac has no bombs, bombs can be placed at the cost of half a heart. |
Bloody Lust | | Increases damage as Isaac receives damage. Damage increase stays for the whole floor. |
Blood Of The Martyr | File:Blood Of The Martyr Icon.png | Increases Damage by 1, and turns Isaac's tears into blood tears. |
Bob's Brain | | Spawns a familiar that charges forward when shooting tears, explodes upon contact with an enemy and poisons them. Respawns after few seconds. |
Bob's Curse | | Gives 5 bombs and grants all bombs poison effect. |
Bobby-Bomb | | Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy. |
The Body | | Adds 3 Heart Containers. |
Boiled Baby | | Grants a familiar similar to a Boil that periodically fires bursts of bullets. |
Bomb Bag | | Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms. |
Boom! | | Gives 10 bombs. |
Bot Fly | | Grants a familiar that fires shielded tears at incoming bullets. |
Brother Bobby | | Follows Isaac around shooting normal tears. |
Bucket Of Lard | File:Bucket Of Lard Icon.png | Grants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2. |
Bum Friend | | A portable Beggar who follows Isaac, picks up coins for himself, and occasionally drops a Pickup after collecting a coin. Does not spawn Collectibles. |
Butt Bombs | | Gives +5 Bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and Confusing all enemies. |
Cain's Other Eye | | Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac. |
Cancer | | Adds 3 Soul Hearts. Grants The Wafer effect for the current room upon taking damage. |
Capricorn | | All stats up. |
Celtic Cross | | Grants a chance to trigger the Book Of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. |
Charm Of The Vampire | File:Charm Of The Vampire Icon.png | Heals the character for half of a red heart for every 13 monsters killed. |
Chemical Peel | | Tears fired from left eye do increased damage. |
Chocolate Milk | | Grants charged tears that deal greater damage when fully charged. |
The Common Cold | | Adds a chance to shoot poison tears, dealing damage over time when inflicted. |
Cricket's Body | | Increases Tears and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's. |
Cricket's Head | | Increases damage by 0.5, and multiplies it by 1.5x. |
Cupid's Arrow | | Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them. |
Cursed Eye | | Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room. |
Daddy Longlegs | | Daddy Long Legs' shadow follows Isaac and stomps on enemies. |
Dark Bum | | Spawns a familiar that follows Isaac around and collects Red Hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one Soul Heart, one hostile Spider or one friendly Blue Spider. |
Dead Bird | | Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage. |
Dead Onion | | Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed. |
Death's Touch | | Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only. |
Demon Baby | | Follows Isaac and automatically fires at enemies in its reach. |
Dirty Mind | | Destroying poop spawns friendly Dips that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. |
Distant Admiration | | A red attack fly circles further out than the Halo Of Flies/Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone. |
Donkey Jawbone | | Isaac does a spin attack that damages nearby enemies whenever he takes damage. Killed enemies have a chance to drop a red heart. |
Dr. Fetus | | Tears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired. |
Dry Baby | | Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot it has a chance of triggering The Necronomicon effect. |
E Coli | | Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into Poop. |
Enigma Bombs | | Grants 5 bombs. Bombs explode with a random bomb effect. |
Epic Fetus | | Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote. |
Eve's Mascara | | Doubles damage, halves tears stat, and greatly reduces shot speed. |
Experimental Treatment | | Randomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times. |
Eye Sore | | Frequently fire tears in random directions in addition to regular tears. Can fire up to three extra tears. |
Fire Mind | | Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion. |
Forever Alone | | Spawns a blue attack fly that orbits a long distance from Isaac. |
Freezer Baby | | Grants a familiar that fires shots that freeze enemies. Frozen enemies explode into ice shards when touched. |
Gemini | | Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range. |
Ghost Baby | | Spawns a familiar that follows Isaac around and fires spectral tears. |
Gimpy | | Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed. |
Gnawed Leaf | | After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. |
Guillotine | | Isaac's head is removed from his body and floats around him. Increases Damage by 1 and Tears by 0.16. |
The Halo | | Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height. |
Halo Of Flies | File:Halo Of Flies Icon.png | Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies. |
Harlequin Baby | | Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. |
Headless Baby | | Familiar that follows Isaac, leaving blood creep on the ground. |
Holy Mantle | | Automatically negates first taken damage in every room. |
Holy Water | | When Isaac receives damage, the bottle breaks and a puddle of blue Creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room. |
Hot Bombs | | Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact. |
Infamy | | Chance to block projectiles coming from any direction. |
Infestation | | 1-3 Blue Flies randomly spawn every time Isaac gets hit. |
Infestation 2 | | Spawns allied blue spiders from killed enemies. |
The Inner Eye | | Grants triple shot but decreases tears. |
The Intruder | | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. |
Ipecac | | Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth. |
Iron Bar | | Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly. |
Isaac's Heart | | Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt. |
It Hurts | | Taking damage causes Isaac to release a ring of bloody tears and increases fire rate for current room. |
Judas' Shadow | | Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts. |
Juicy Sack | | A Familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 Blue Spiders after each room. |
Knockout Drops | | Adds a chance to fire fist tears, which have massive knockback and briefly stun enemies. |
Lazarus' Rags | | Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item. |
Leech | | Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one. |
Leo | | Allows you to crush rocks when you walk over them. |
Libra | | Gives 6 coins, 6 bombs and 6 keys and balances out all attributes. |
Lil' Brimstone | File:Lil' Brimstone Icon.png | A Familiar that shoots a small Brimstone beam. Must charge like the Brimstone Item before shooting. |
Lil' Dumpy | | Grants a familiar that loosely follows Isaac. It farts when hit by enemy attacks, poisoning or stunning enemies and sending it bouncing away. |
Lil' Haunt | File:Lil' Haunt Icon.png | A familiar that damages enemies by chasing them as well as inducing the fear effect. |
Little C.H.A.D. | | A Familiar who will drop a half Heart every 2 rooms. |
Little Chubby | | A Familiar that charges forward and deals touch damage to any enemies in its path. |
Little Gish | | Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. |
Little Steven | | Spawns a familiar that follows Isaac around and fires homing tears. |
Lodestone | | Adds a chance to fire magnetizing tears. Magnetized enemies attract other enemies, Isaac's tears, and enemy shots including their own. |
Loki's Horns | | Gives a random chance for projectiles to fire in all 4 cardinal directions. |
Lost Contact | | Every tear has a small shield which will allow it to block one enemy projectile. |
Lost Soul | | Spawns a Lost familiar that follows Isaac. It dies if hit by an enemy, regenerating on the next floor. If it survives an entire floor, it grants a random reward. |
Lucky Foot | | +1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat) |
The Ludovico Technique | | Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy. |
Maggy's Bow | | Gives one heart container and doubles the healing provided by red hearts. |
Magic Mushroom | | Increases all stats and enlargens Isaac |
Magneto | | Pulls Pickups towards Isaac. |
Member Card | | Opens a trapdoor with a ladder in every shop. The trapdoor leads to a special shop room, which sells multiple items or pickups for random prices. Sold collectibles don't have to be from the Shop pool. |
Midas' Touch | | Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin. |
The Mind | | Grants the combined effects of the Blue Map, Treasure Map and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms. |
Mini Mush | | Increases Speed and Shot Height and decreases Isaac's size, but lowers Range. |
Mitre | | Grants a chance of converting any red hearts pickups into soul hearts instead. |
Mom's Contacts | | Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up. |
Mom's Eyeshadow | | Tears have a chance to charm enemies. |
Mom's Eye | | Allows Isaac to fire tears from the back of his head. |
Mom's Knife | | Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power. |
Mom's Perfume | | Adds a chance to shoot fear tears and increases Tears by 0.16. |
Mom's Wig | | Adds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart. |
Money = Power | | Increases damage by 0.04 for every coin Isaac has up to +3.96 damage at 99 coins. |
Mongo Baby | | Summons a familiar that copies the tears of Isaac's other familiars. |
Monstro's Lung | | Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro. |
Mr. Mega | | Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage. |
Mucormycosis | | Enemies release a cloud of gas upon death that damages and poisons other enemies. |
The Mulligan | | Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy. |
Mutant Spider | | Grants quadruple shot but decreases tears. |
My Reflection | | Gives Isaac's tears a boomerang effect, and increases range and shot speed. |
Mysterious Liquid | | Tears leave a small, short lasting pool of creep on impact or when their range is depleted. |
Mystery Sack | | Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or key after clearing a room. |
Number One | | Tears range is heavily decreased, but the fire rate is greatly increased. |
Odd Mushroom (Large) | | Grants an empty heart container. Increases damage, range and shot height while reducing speed. |
Odd Mushroom (Thin) | | Increases Tears and Speed while reducing Damage. |
Orphan Socks | | Grants +0.15 Speed and two Soul Hearts. Isaac can walk on harmful floor effects without taking damage. |
Ouija Board | | Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them. |
The Parasite | | Isaac's tears split in two when they hit something. |
The Peeper | | Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to boom flies damaging enemies it passes through. |
PHD | | Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup. |
Piggy Bank | | Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny. |
Pisces | | Increases tears, adds knock-back shots and increases tear size. |
Playdoh Cookie | | Grants multicolored tears, which can be normal, petrifying, homing, poisoning, or fear-inducing based on their color. |
Polyphemus | | Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage. |
Proptosis | | Tears start out massive with high damage, and then shrink down and become weaker over a short range. |
Punching Bag | | Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer. |
Pyromaniac | | Isaac heals 1 heart instead of taking damage by a explosive blast from source. Adds 5 bombs. |
Pyro | | Adds 99 bombs. |
Rainbow Baby | | Spawns a familiar that follows Isaac around and fires tears with random effects. |
The Relic | | Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms. |
Robo-Baby | | Follows Isaac around, shooting enemies with an eye laser similar to Technology. |
Robo-Baby 2.0 | | Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears |
Rocket In A Jar | | Grants 5 bombs. Bombs become rockets that fly in the direction Isaac is currently looking. |
Roid Rage | | Increases speed by 0.6, range by 5.25, and tear height by 0.5. |
Rosary | | Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool. |
Rotten Baby | | A familiar that spawns Blue Flies. |
Rotten Tomato | | Tears have a chance to mark enemies. Marked enemies will be attacked by other enemies. |
Rubber Cement | | Tears bounce off walls and obstacles (including enemies). |
SMB Super Fan | | Increases all stats. |
Sack Of Pennies | File:Sack Of Pennies Icon.png | Isaac is followed by a small bag that drops a coin every 2 rooms. |
Sacrificial Dagger | | Dagger orbits Isaac, dealing very high damage. |
Sad Bombs | | +5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears. |
The Sad Onion | | Increases Tears by 0.7. |
Sagittarius | | Increases speed by +0.2 and grants piercing tears. |
Samson's Chains | | Pull a chain and ball behind you that will damage enemies on contact and is able to break stones. |
Scapular | | Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart. |
Scorpio | | Grants poison tears, which deal damage over time when inflicted. |
Sissy Longlegs | | Wanders about the room, occasionally spawning Blue Spiders. |
Sister Maggy | | A Familiar that follows Isaac around shooting blood tears. |
Smart Fly | | After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared. |
The Soul | | Grants two Soul Hearts. Isaac now repels enemy projectiles. |
Soy Milk | | Tears shrink and do much less damage, but fire in very rapid succession. |
Speed Ball | | Increases speed by 0.3 and shot speed by 20%. |
Spelunker Hat | | Reveals type of adjacent rooms, including location for secret rooms and super secret rooms. |
Spider Bite | | Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them. |
Spider Baby | | When hit, spawns up to 2 Blue Spiders. |
Spoon Bender | | Grants Isaac homing tears. |
Stem Cells | | Adds one filled Heart Container and increases Shot Speed. |
Stigmata | | Increases damage, and adds 1 heart container. |
Stone Bombs | | Grants 5 bombs. Bombs release rock waves in the cardinal directions, which can damage enemies, destroy obstacles, and damage Isaac. |
Strange Attractor | | Pickups, Trinkets and Monsters are magnetically attracted to Isaac's tears. |
Super Bandage | | Grants one Heart Container and gives 2 Soul Hearts. |
Taurus | | Speed down, gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds. |
Tech.5 | | Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet. |
Technology 2 | | Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously. |
Technology | | Replaces tears with a piercing laser with unlimited range. |
Thunder Thighs | | Destroys rocks upon contact with Isaac. Adds one heart container, and lowers Speed. |
Tiny Planet | | Range up and makes shot tears revolve around Isaac until they drop. |
Tinytoma | | A large familiar slowly orbits Isaac. Upon taking enough damage, it splits into two smaller orbitals. If they take enough damage, they burst into blue spiders and the large orbital respawns. |
Tough Love | | Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears. |
Virgo | | Grants a chance to trigger the Book Of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills". |
The Virus | | Inflicts poison to enemies who make contact with Isaac. Speed down. |
The Wafer | | All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead. |
X-Ray Vision | | Reveals and opens all Secret Room and Super Secret Room entrances. |