Treasure Room (Antibirth Item Pool)

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Item Pool
Rebirth Treasure Room Shop Library Curse Room Boss Secret Room Devil Room Angel Room Golden Chest Red Chest Beggar Devil Beggar Key Master
Antibirth Treasure Room Shop Library Curse Room Boss Secret Room Devil Room Angel Room Golden Chest Red Chest Beggar Devil Beggar Key Master Planetarium

The treasure room item pool contains the majority of the game's items. All of the items in this pool are able to be found in the Treasure Room.

Activated Collectibles[edit | edit source]

Name Icon Description Recharge
Anarchist CookbookCollectible Anarchist Cookbook icon.pngSpawns six troll bombs around the room.3
The BeanCollectible The Bean icon.pngIsaac releases bad gas, poisoning any enemy in close vicinity.1
Best FriendCollectible Best Friend icon.pngDeploys a decoy Isaac that eventually explodes with an increased blast radius.3
Blank CardCollectible Blank Card icon.pngHas the same effect as the card or rune currently held by Isaac.4
Blood RightsCollectible Blood Rights icon.pngDamages all enemies in the room, but deals a half-heart of damage to Isaac with each use.0
Bob's Rotten HeadCollectible Bob's Rotten Head icon.pngUpon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.3
Book Of DespairBook Of Despair Icon.pngIncreases tears for the current room.3
Book Of Revelations45x45pxAdds 1 Soul Heart and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).6
Book Of Secrets45x45pxUpon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.6
Book Of Shadows45x45pxUpon use, creates a protective shield nullifying all types of damage for 10 seconds.3
The Book Of Sin45x45pxSpawns a random Pick Up, Pill, Card, or Trinket.4
Box Of Spiders45x45pxSummons 2-4 Blue Spiders.2
Butter BeanCollectible Butter Bean icon.pngIsaac farts and pushes back nearby enemies.3 seconds
Crack The Sky45x45pxSummons multiple beams of light in random locations around the room, dealing a large amount of damage to any enemy that touches them.4
Crystal BallCollectible Crystal Ball icon.pngReveals the map (except the Super Secret Room) and drops a random Tarot Card or Soul Heart.6
D100Collectible D100 icon.pngUpon use, rerolls all passive items on Isaac like the D4, every pedestal item in the room like the D6 and every pickup like the D20.6
D10Collectible D10 icon.pngRerolls the enemies in a room. Only rerolls enemies that are still alive (does not spawn new enemies).1
D12D12 Antibirth Icon.pngRe-rolls all rocks in the current room into other random objects, such as bomb rocks, metal blocks, TNT, or poop.3
D20Collectible D20 icon.pngRerolls all pickups in the current room.6
D4Collectible D4 icon.pngRerolls all upgrades on the player. (Does not reroll Azazel's brimstone).6
The D6Collectible The D6 icon.pngAllows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.6
Dad's KeyCollectible Dad's Key icon.pngOpens all doors in the current room when activated, including doors which require a Key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and The Dark Room.2
Dead Sea ScrollsCollectible Dead Sea Scrolls icon.pngTriggers the effect of a random activated item from a list of possible options (not every activated item is included).2
Deck Of Cards45x45pxGives Isaac a random Tarot Card.6
Doctor's RemoteCollectible Doctor's Remote icon.pngSets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with tear controls. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.2
Eternal D6Eternal D6 Icon.pngRerolls items with chance of disappearing.3
Flush!Collectible Flush! icon.pngChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.6
Forget Me NowCollectible Forget Me Now icon.pngWhen activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.One time use
Fortune CookieFortune Cookie Icon.pngDisplays a random fortune, and has a chance to drop a soul heart, card, rune or trinket.2
Free LemonadeFree Lemonade Icon.pngCreates a large puddle of lemonade that damages enemies.4
The GamekidCollectible The Gamekid icon.pngUpon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability and increased speed, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.6
The HourglassCollectible The Hourglass icon.pngUpon activation, enemies and their projectiles are slowed down for a short duration.2
How To Jump45x45pxGives Isaac the ability to jump (over gaps, spikes, etc.).0
Isaac's TearsCollectible Isaac's Tears icon.pngShoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.6
Kamikaze!Collectible Kamikaze! icon.pngCreates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.0
Lemon MishapCollectible Lemon Mishap icon.pngCreates a small yellow pool of Creep, which damages enemies that cross it.2
Magic FingersCollectible Magic Fingers icon.pngFor 1 Coin, damages all enemies in the room.0
Meat CleaverMeat Cleaver Icon.pngSplits all enemies in a room into 2 smaller versions of themselves with lower health.2
Mom's Bottle Of Pills45x45pxGives Isaac a random Pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.6
Mom's BraCollectible Mom's Bra icon.pngUpon use, petrifies all enemies in the current room for approximately 4 seconds.3
Mom's PadCollectible Mom's Pad icon.pngUpon use, inflicts fear to all enemies in the room for 5 seconds.3
Monster ManualCollectible Monster Manual icon.pngSummons a random familiar for the current room. Can summon familiars not yet unlocked.3
Monstro's ToothCollectible Monstro's Tooth icon.pngMonstro jumps onto a random enemy, doing area damage. Can damage/kill the player if summoned in an room without enemies.3
Mr. BoomCollectible Mr. Boom icon.pngDrops a large bomb.2
My Little UnicornCollectible My Little Unicorn icon.pngUpon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and instead dealing contact damage to enemies.6
Notched AxeCollectible Notched Axe icon.pngIsaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items.3
The Pinking ShearsCollectible The Pinking Shears icon.pngSeparates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.6
The PoopCollectible The Poop icon.pngSpawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.1
Prayer CardCollectible Prayer Card icon.pngGrants an Eternal Heart per use.6
Remote DetonatorCollectible Remote Detonator icon.pngBombs you place explode only when you use this item. Gives 5 bombs.0
Satanic BibleCollectible Satanic Bible icon.pngUpon activation, Isaac gains a black heart.6
ScissorsCollectible Scissors icon.pngUpon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage.File:NoDLC Indicator.png6
File:DLC Indicator.png 2
The ScooperThe Scooper Icon.pngSummons a Peep familiar for the current room, which leaves a trail of red creep.3
Shoop Da Whoop!Collectible Shoop Da Whoop! icon.pngFires a laser from Isaac's mouth.2
Spider ButtCollectible Spider Butt icon.pngDamages all enemies in the room and slows them and their projectiles down.2
StitchesStitches Icon.pngSpawns a familiar that flies diagonally across the room, switching direction upon hitting walls. Activating the item swaps the positions of Isaac and Stitches.3 seconds
Telepathy For Dummies45x45pxUpon activation, grants homing tears for the current room.2
TeleportCollectible Teleport icon.pngTeleports you to a random room on the level.2
UndefinedCollectible Undefined icon.pngTeleports Isaac to either the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR.6
Unicorn StumpCollectible Unicorn Stump icon.pngUpon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.1
Yuck HeartYuck Heart Icon.pngUpon use, grants a rotten heart.4
Yum HeartCollectible Yum Heart icon.pngRestores 1 whole Red heart.4

Passive Collectibles[edit | edit source]

Name Icon Description
120 Volt120 Volt Icon.pngWhenever an enemy is shot, it will zap other enemies near them, dealing damage.
20/20Collectible 20 20 icon.pngGrants double shot.
3 Dollar BillCollectible 3 Dollar Bill icon.pngGives Isaac a random tear effect every room. The effect given changes upon entering a room. File:DLC Indicator.png The effect changes every 3 seconds.
???'s Only FriendCollectible Blue Baby's Only Friend icon.pngSummons a big attack fly that can be controlled with the shooting direction-keys.
A Quarter45x45pxAdds 25 to Isaac's coin count, capping at 99.
AbelCollectible Abel icon.pngA familiar that mirrors the player's movements and shoots in the opposite direction.
AkeldamaAkeldama Icon.pngWhenever Isaac fires a shot, a bloody tear will spawn behind him. Multiple tears will form a trail of tears that drags behind Isaac as he moves, bursting and dealing damage upon contact with enemies. Multiple trails can be formed.
Almond MilkAlmond Milk Icon.pngUpgrades fire rate immensely but significantly decreases damage, and tears are given random worm effects.
AnemicCollectible Anemic icon.png+5 Range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
AnkhCollectible Ankh icon.pngUpon death, the player will respawn as Blue Baby with 3 Soul Hearts.
Anti-GravityCollectible Anti-Gravity icon.pngTears up. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
AquariusCollectible Aquarius icon.pngA trail of blue creep is left behind Isaac, which damages enemies.
AriesCollectible Aries icon.png+0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.
BBFCollectible BBF icon.pngSpawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Ball Of Tar45x45pxAdds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Best BudCollectible Best Bud icon.pngWhen hit, summons a white attack fly similar to Distant Admiration for the current room.
Big FanCollectible Big Fan icon.pngSpawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Bird CageBird Cage Icon.pngUpon taking damage the first time in a room, the familiar leaps from Isaac's head, targets an enemy, and lands on them, dealing damage and releasing a rock wave. For the rest of the room, the familiar targets and attacks enemies similar to Dead Bird.
Bird's EyeBird's Eye Icon.pngAdds a chance to spit a large fire whenever Isaac fires a tear.
The Black BeanCollectible The Black Bean icon.pngWhen taking damage, Isaac farts, causing poison damage to all enemies in range.
Blood BombsBlood Bombs Icon.pngGrants 1 heart container. Bombs create puddles of damaging red creep upon exploding. If Isaac has no bombs, bomb can be placed at the cost of half a heart.
Bloody LustCollectible Bloody Lust icon.pngIncreases damage as Isaac receives damage. Damage increase stays for the whole floor.
Blood Of The Martyr45x45pxIncreases Damage by 1, and turns Isaac's tears into blood tears.
Bob's BrainCollectible Bob's Brain icon.pngSpawns a familiar that charges forward when shooting tears, explodes upon contact with an enemy and poisons them. Respawns after few seconds.
Bob's CurseCollectible Bob's Curse icon.pngGives 5 bombs and grants all bombs poison effect.
Bobby-BombCollectible Bobby-Bomb icon.pngGives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
The BodyCollectible The Body icon.pngAdds 3 Heart Containers.
Boiled BabyBoiled Baby Icon.pngGrants a familiar similar to a Boil that periodically fires bursts of bullets.
Bomb BagCollectible Bomb Bag icon.pngIsaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Boom!Collectible Boom! icon.pngGives 10 bombs.
Bot FlyBot Fly Icon.pngGrants a familiar that fires shielded tears at incoming bullets.
Brother BobbyCollectible Brother Bobby icon.pngFollows Isaac around shooting normal tears.
Bucket Of Lard45x45pxGrants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.
Bum FriendCollectible Bum Friend icon.pngA portable Beggar who follows Isaac, picks up coins for himself, and occasionally drops a Pickup after collecting a coin. Does not spawn Collectibles.
Butt BombsCollectible Butt Bombs icon.pngGives +5 Bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and Confusing all enemies.
Cain's Other EyeCollectible Cain's Other Eye icon.pngSpawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.
CancerCollectible Cancer icon.pngAdds 3 Soul Hearts. Grants The Wafer effect for the current room upon taking damage.
CapricornCollectible Capricorn icon.pngAll stats up.
Celtic CrossCollectible Celtic Cross icon.pngGrants a chance to trigger the Book Of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Charm Of The Vampire45x45pxHeals the character for half of a red heart for every 13 monsters killed.
Chemical PeelCollectible Chemical Peel icon.pngTears fired from left eye do increased damage.
Chocolate MilkCollectible Chocolate Milk icon.pngGrants charged tears that deal greater damage when fully charged.
The Common ColdCollectible The Common Cold icon.pngAdds a chance to shoot poison tears, dealing damage over time when inflicted.
Cricket's BodyCollectible Cricket's Body icon.pngIncreases Tears and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.
Cricket's HeadCollectible Cricket's Head icon.pngIncreases damage by 0.5, and multiplies it by 1.5x.
Cupid's ArrowCollectible Cupid's Arrow icon.pngGrants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Cursed EyeCollectible Cursed Eye icon.pngGrants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
Daddy LonglegsCollectible Daddy Longlegs icon.pngDaddy Long Legs' shadow follows Isaac and stomps on enemies.
Dark BumCollectible Dark Bum icon.pngSpawns a familiar that follows Isaac around and collects Red Hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one Soul Heart, one hostile Spider or one friendly Blue Spider.
Dead BirdCollectible Dead Bird icon.pngSpawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
Dead OnionCollectible Dead Onion icon.pngGrants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Death's TouchCollectible Death's Touch icon.pngIncreases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Demon BabyCollectible Demon Baby icon.pngFollows Isaac and automatically fires at enemies in its reach.
Dirty MindDirty Mind Icon.pngDestroying poop spawns friendly Dips that follow the player and damage enemies. Destroying different types of poop spawns different Dips with special effects.
Distant AdmirationCollectible Distant Admiration icon.pngA red attack fly circles further out than the Halo Of Flies/Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Donkey JawboneDonkey Jawbone Icon.pngWhenever Isaac takes damage, a spin attack will damage enemies around him.
Dr. FetusCollectible Dr. Fetus icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.
Dry BabyCollectible Dry Baby icon.pngSpawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot it has a chance of triggering The Necronomicon effect.
E ColiCollectible E Coli icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into Poop.
Enigma BombsEnigma Bombs Icon.pngGrants 5 bombs. Bombs explode with a random bomb effect.
Epic FetusCollectible Epic Fetus icon.pngIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Eve's MascaraCollectible Eve's Mascara icon.pngDoubles damage, halves tears stat, and greatly reduces shot speed.
Experimental TreatmentCollectible Experimental Treatment icon.pngRandomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Eye SoreEye Sore Icon.pngFrequently fire tears in random directions in addition to regular tears. Can fire up to three extra tears.
Fire MindCollectible Fire Mind icon.pngGrants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Forever AloneCollectible Forever Alone icon.pngSpawns a blue attack fly that orbits a long distance from Isaac.
Freezer BabyFreezer Baby Icon.pngGrants a familiar that fires shots that freeze enemies. Frozen enemies explode into ice shards when touched.
GeminiCollectible Gemini icon.pngSuture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
Ghost BabyCollectible Ghost Baby icon.pngSpawns a familiar that follows Isaac around and fires spectral tears.
GimpyCollectible Gimpy icon.pngHas a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Gnawed LeafCollectible Gnawed Leaf icon.pngAfter standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
GuillotineCollectible Guillotine icon.pngIsaac's head is removed from his body and floats around him. Increases Damage by 1 and Tears by 0.16.
The HaloCollectible The Halo icon.pngGrants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Halo Of Flies45x45pxSpawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Harlequin BabyCollectible Harlequin Baby icon.pngSpawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless BabyCollectible Headless Baby icon.pngFamiliar that follows Isaac, leaving blood creep on the ground.
Holy MantleCollectible Holy Mantle icon.pngAutomatically negates first taken damage in every room.
Holy WaterCollectible Holy Water icon.pngWhen Isaac receives damage, the bottle breaks and a puddle of blue Creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Hot BombsCollectible Hot Bombs icon.pngGrants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
InfamyCollectible Infamy icon.pngChance to block projectiles coming from any direction.
InfestationCollectible Infestation icon.png1-3 Blue Flies randomly spawn every time Isaac gets hit.
Infestation 2Collectible Infestation 2 icon.pngSpawns allied blue spiders from killed enemies.
The Inner EyeCollectible The Inner Eye icon.pngGrants triple shot but decreases tears.
The IntruderThe Intruder Icon.pngIsaac will now fire four slowing tears in addition to normal tears. Upon taking damage multiple times in one room, Isaac's head will pop, spawning friendly spiders and a familiar that leaps at enemies.
IpecacCollectible Ipecac icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Iron BarCollectible Iron Bar icon.pngIncreases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Isaac's HeartCollectible Isaac's Heart icon.pngIsaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
It HurtsIt Hurts Icon.pngTaking damage causes Isaac to release a ring of bloody tears and increases fire rate for current room.
Judas' ShadowCollectible Judas' Shadow icon.pngAdds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Juicy SackCollectible Juicy Sack icon.pngA Familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 Blue Spiders after each room.
Knockout DropsKnockout Drops Icon.pngAdds a chance to fire fist tears, which have massive knockback and briefly stun enemies.
Lazarus' RagsCollectible Lazarus' Rags icon.pngUpon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
LeechCollectible Leech icon.pngSpawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.
LeoCollectible Leo icon.pngAllows you to crush rocks when you walk over them.
LibraCollectible Libra icon.pngGives 6 coins, 6 bombs and 6 keys and balances out all attributes.
Lil' Brimstone45x45pxA Familiar that shoots a small Brimstone beam. Must charge like the Brimstone Item before shooting.
Lil' DumpyLil' Dumpy Icon.pngGrants a familiar that loosely follows the player. Farts when hit by enemy attacks.
Lil' Haunt45x45pxA familiar that damages enemies by chasing them as well as inducing the fear effect.
Little C.H.A.D.Collectible Little C.H.A.D. icon.pngA Familiar who will drop a half Heart every 2 rooms.
Little ChubbyCollectible Little Chubby icon.pngA Familiar that charges forward and deals touch damage to any enemies in its path.
Little GishCollectible Little Gish icon.pngSpawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Little StevenCollectible Little Steven icon.pngSpawns a familiar that follows Isaac around and fires homing tears.
LodestoneLodestone Icon.pngAdds a chance to fire magnetizing tears. Magnetized enemies attract other enemies, Isaac's tears, and enemy shots including their own.
Loki's HornsCollectible Loki's Horns icon.pngGives a random chance for projectiles to fire in all 4 cardinal directions.
Lost ContactCollectible Lost Contact icon.pngEvery tear has a small shield which will allow it to block one enemy projectile.
Lost SoulLost Soul Icon.pngSpawns a familiar version of The Lost that follows Isaac. Upon being hit, it instantly dies, regenerating on the next floor. If it survives an entire floor, it grants a random reward.
Lucky FootCollectible Lucky Foot icon.png+1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat)
The Ludovico TechniqueCollectible The Ludovico Technique icon.pngInstead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Maggy's BowCollectible Maggy's Bow icon.pngGives one heart container and doubles the healing provided by red hearts.
Magic MushroomCollectible Magic Mushroom icon.pngIncreases all stats and enlargens Isaac
MagnetoCollectible Magneto icon.pngPulls Pickups towards Isaac.
Member CardMember Card Icon.pngOpens a trapdoor with a ladder in every shop. The trapdoor leads to a special shop room, which sells multiple items or pickups for random prices. Sold collectibles don't have to be from the Shop pool.
Midas' TouchCollectible Midas' Touch icon.pngEnemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
The MindCollectible The Mind icon.pngGrants the combined effects of the Blue Map, Treasure Map and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
Mini MushCollectible Mini Mush icon.pngIncreases Speed and Shot Height and decreases Isaac's size, but lowers Range.
MitreCollectible Mitre icon.pngGrants a chance of converting any red hearts pickups into soul hearts instead.
Mom's ContactsCollectible Mom's Contacts icon.pngAdds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Mom's EyeshadowCollectible Mom's Eyeshadow icon.pngTears have a chance to charm enemies.
Mom's EyeCollectible Mom's Eye icon.pngAllows Isaac to fire tears from the back of his head.
Mom's KnifeCollectible Mom's Knife icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Mom's PerfumeCollectible Mom's Perfume icon.pngAdds a chance to shoot fear tears and increases Tears by 0.16.
Mom's WigCollectible Mom's Wig icon.pngAdds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart.
Money = PowerCollectible Money = Power icon.pngIncreases damage by 0.04 for every coin Isaac has up to +3.96 damage at 99 coins.
Mongo BabyCollectible Mongo Baby icon.pngSummons a familiar that copies the tears of Isaac's other familiars.
Monstro's LungCollectible Monstro's Lung icon.pngIncreases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Mr. MegaCollectible Mr. Mega icon.pngGives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
MucormycosisMucormycosis Icon.pngUpon enemies' death, they release a cloud of gas that damages and poisons other enemies.
The MulliganCollectible The Mulligan icon.pngTears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Mutant SpiderCollectible Mutant Spider icon.pngGrants quadruple shot but decreases tears.
My ReflectionCollectible My Reflection icon.pngGives Isaac's tears a boomerang effect, and increases range and shot speed.
Mysterious LiquidCollectible Mysterious Liquid icon.pngTears leave a small, short lasting pool of creep on impact or when their range is depleted.
Mystery SackCollectible Mystery Sack icon.pngSpawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or key after clearing a room.
Number OneCollectible Number One icon.pngTears range is heavily decreased, but the fire rate is greatly increased.
Odd Mushroom (Large)Collectible Odd Mushroom (Large) icon.pngGrants an empty heart container. Increases damage, range and shot height while reducing speed.
Odd Mushroom (Thin)Collectible Odd Mushroom (Thin) icon.pngIncreases Tears and Speed while reducing Damage.
Orphan SocksOrphan Socks Icon.pngIsaac gains 2 spirit hearts and can walk on harmful floor effects.
Ouija BoardCollectible Ouija Board icon.pngGrants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
The ParasiteCollectible The Parasite icon.pngIsaac's tears split in two when they hit something.
The PeeperCollectible The Peeper icon.pngSpawns a familiar that floats slowly around the room on a zig-zag pattern similar to boom flies damaging enemies it passes through.
PHDCollectible PHD icon.pngConverts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.
Piggy BankCollectible Piggy Bank icon.pngGives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.
PiscesCollectible Pisces icon.pngIncreases tears, adds knock-back shots and increases tear size.
Playdoh CookiePlaydoh Cookie Icon.pngAdds random effects to tears.
PolyphemusCollectible Polyphemus icon.pngMakes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
ProptosisCollectible Proptosis icon.pngTears start out massive with high damage, and then shrink down and become weaker over a short range.
Punching BagCollectible Punching Bag icon.pngSpawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
PyromaniacCollectible Pyromaniac icon.pngIsaac heals 1 heart instead of taking damage by a explosive blast from source. Adds 5 bombs.
PyroCollectible Pyro icon.pngAdds 99 bombs.
Rainbow BabyCollectible Rainbow Baby icon.pngSpawns a familiar that follows Isaac around and fires tears with random effects.
The RelicCollectible The Relic icon.pngIsaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
Robo-BabyCollectible Robo-Baby icon.pngFollows Isaac around, shooting enemies with an eye laser similar to Technology.
Robo-Baby 2.0Collectible Robo-Baby 2.0 icon.pngFires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears
Rocket In A JarRocket In A Jar Icon.pngGrants 5 bombs. Bombs become rockets that fly in the direction Isaac is currently looking.
Roid RageCollectible Roid Rage icon.pngIncreases speed by 0.6, range by 5.25, and tear height by 0.5.
RosaryCollectible Rosary icon.pngAdds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Rotten BabyCollectible Rotten Baby icon.pngA familiar that spawns Blue Flies.
Rotten TomatoRotten Tomato Icon.pngTears have a chance to mark enemies. Marked enemies will be attacked by other enemies.
Rubber CementCollectible Rubber Cement icon.pngTears bounce off walls and obstacles (including enemies).
SMB Super FanCollectible SMB Super Fan icon.pngIncreases all stats.
Sack Of Pennies45x45pxIsaac is followed by a small bag that drops a coin every 2 rooms.
Sacrificial DaggerCollectible Sacrificial Dagger icon.pngDagger orbits Isaac, dealing very high damage.
Sad BombsCollectible Sad Bombs icon.png+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
The Sad OnionCollectible The Sad Onion icon.pngIncreases Tears by 0.7.
SagittariusCollectible Sagittarius icon.pngIncreases speed by +0.2 and grants piercing tears.
Samson's ChainsCollectible Samson's Chains icon.pngPull a chain and ball behind you that will damage enemies on contact and is able to break stones.
ScapularCollectible Scapular icon.pngOnce per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.
ScorpioCollectible Scorpio icon.pngGrants poison tears, which deal damage over time when inflicted.
Sissy LonglegsCollectible Sissy Longlegs icon.pngWanders about the room, occasionally spawning Blue Spiders.
Sister MaggyCollectible Sister Maggy icon.pngA Familiar that follows Isaac around shooting blood tears.
Smart FlyCollectible Smart Fly icon.pngAfter Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
The SoulCollectible The Soul icon.pngGrants two Soul Hearts. Isaac now repels enemy projectiles.
Soy MilkCollectible Soy Milk icon.pngTears shrink and do much less damage, but fire in very rapid succession.
Speed BallCollectible Speed Ball icon.pngIncreases speed by 0.3 and shot speed by 20%.
Spelunker HatCollectible Spelunker Hat icon.pngReveals type of adjacent rooms, including location for secret rooms and super secret rooms.
Spider BiteCollectible Spider Bite icon.pngAdds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spider BabyCollectible Spider Baby icon.pngWhen hit, spawns up to 2 Blue Spiders.
Spoon BenderCollectible Spoon Bender icon.pngGrants Isaac homing tears.
Stem CellsCollectible Stem Cells icon.pngAdds one filled Heart Container and increases Shot Speed.
StigmataCollectible Stigmata icon.pngIncreases damage, and adds 1 heart container.
Stone BombsStone Bombs Icon.pngGrants 5 bombs. Bombs release rock waves in the cardinal directions, which can damage enemies, destroy obstacles, and damage Isaac.
Strange AttractorCollectible Strange Attractor icon.pngPickups, Trinkets and Monsters are magnetically attracted to Isaac's tears.
Super BandageCollectible Super Bandage icon.pngGrants one Heart Container and gives 2 Soul Hearts.
TaurusCollectible Taurus icon.pngSpeed down, gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Tech.5Collectible Tech.5 icon.pngGrants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.
Technology 2Collectible Technology 2 icon.pngDecreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
TechnologyCollectible Technology icon.pngReplaces tears with a piercing laser with unlimited range.
Thunder ThighsCollectible Thunder Thighs icon.pngDestroys rocks upon contact with Isaac. Adds one heart container, and lowers Speed.
Tiny PlanetCollectible Tiny Planet icon.pngRange up and makes shot tears revolve around Isaac until they drop.
TinytomaTinytoma Icon.pngA large orbital that slowly orbits Isaac. Upon taking enough tear or contact damage, the orbital splits into two smaller ones that orbit opposite of each other. If the small orbitals take enough damage, they burst into a few blue spiders, and the large orbital respawns.
Tough LoveCollectible Tough Love icon.pngAdds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
VirgoCollectible Virgo icon.pngGrants a chance to trigger the Book Of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
The VirusCollectible The Virus icon.pngInflicts poison to enemies who make contact with Isaac. Speed down.
The WaferCollectible The Wafer icon.pngAll sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
X-Ray VisionCollectible X-Ray Vision icon.pngReveals and opens all Secret Room and Super Secret Room entrances.


Sacdag.png Antibirth Sacdag.png

Boss Baby Plum.png Bosses MainPageChallenges.png Challenges MainPageChapters.png Chapters Character.png Characters Book of Virtues.png Items
Dumpling.png Monsters Bucket.png Objects Immortal Heart.png Pickups Blessed Penny Icon.png Trinkets MainPageAchievements.png Unlockables